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14-645M IRR Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266. For use in Kinase Assays.

14-645M
250 µg  Also available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-645M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionIRR Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman IRR, amino acids 944-1266 expressed by baculovirus in Sf21 cells.
Entrez Gene Number
Gene Symbol
  • INSRR
  • IRR
Protein TargetIRR
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
SIZE: 1297 amino acids; 143720 Da
SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.
Molecular Weight37.9kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of MBP (13-104).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-645M 04053252924538

Documentation

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-645 IRR Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases