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239806 InSolution™ Cyclopamine, V. californicum - Calbiochem

The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Shh Signaling Antagonist I in EtOH

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239806
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₇H₄₁NO₂

Products

Catalog NumberPackaging Qty/Pack
239806-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
Catalogue Number239806
Brand Family Calbiochem®
SynonymsShh Signaling Antagonist I in EtOH
References
ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Product Information
FormLiquid
FormulationSupplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
Hill FormulaC₂₇H₄₁NO₂
Chemical formulaC₂₇H₄₁NO₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 10

Flammable.
S PhraseS: 16-7

Keep away from sources of ignition - No Smoking.
Keep container tightly closed.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
239806-5MG 04055977198911

Documentation

InSolution™ Cyclopamine, V. californicum - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Cyclopamine, V. californicum - Calbiochem Certificates of Analysis

TitleLot Number
239806

References

Reference overview
Berman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
SynonymsShh Signaling Antagonist I in EtOH
DescriptionA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
FormLiquid
FormulationSupplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₇H₄₁NO₂
Structure formulaStructure formula
Purity≥97% by NMR
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Flammable
ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.