528151 Sigma-AldrichInSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem
The InSolution™ PARP Inhibitor VIII, PJ34 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The InSolution™ PARP Inhibitor VIII, PJ34 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl
Recommended Products
Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 344458-19-1 | C₁₇H₁₇N₃O₂ • HCl |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 528151-2MG | Glass bottle | 2 mg |
| Description | |
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| Overview | A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528151) is also available. |
| Catalogue Number | 528151 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl |
| References | |
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| References | Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561. |
| Product Information | |
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| CAS number | 344458-19-1 |
| Form | Liquid |
| Formulation | A 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O. |
| Hill Formula | C₁₇H₁₇N₃O₂ • HCl |
| Chemical formula | C₁₇H₁₇N₃O₂ • HCl |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | PARP |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 528151-2MG | 04055977196429 |
Documentation
InSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem SDS
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InSolution™ PARP Inhibitor VIII, PJ34 - CAS 344458-19-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 528151 |
References
| Reference overview |
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| Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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