527451 Sigma-AldrichInSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem
The InSolution™ PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
Recommended Products
Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 608512-97-6 | C₁₃H₈N₄OS |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 527451-5MG | Glass bottle | 5 mg |
| Description | |
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| Overview | An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available. |
| Catalogue Number | 527451 |
| Brand Family | Calbiochem® |
| Synonyms | C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I |
| References | |
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| References | Zhu, P.J., et al. 2011. Cell 147, 1384. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50. |
| Product Information | |
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| CAS number | 608512-97-6 |
| Form | Liquid |
| Formulation | A 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO. |
| Hill Formula | C₁₃H₈N₄OS |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | PKR |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 527451-5MG | 04055977270372 |
Documentation
InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem SDS
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InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 527451 |
References
| Reference overview |
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| Zhu, P.J., et al. 2011. Cell 147, 1384. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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