557404 Sigma-AldrichInSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
The InSolution™ RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The InSolution™ RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
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| 577784-91-9 | C₁₉H₁₅Cl₂N₃O₂S₂ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 557404-5MG | Glass bottle | 5 mg |
| Description | |
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| Overview | A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available. |
| Catalogue Number | 557404 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide |
| References | |
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| References | Wu, L., et al. 2003. Euk. Cell 2, 256. |
| Product Information | |
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| CAS number | 577784-91-9 |
| Form | Liquid |
| Formulation | A 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO. |
| Hill Formula | C₁₉H₁₅Cl₂N₃O₂S₂ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | RNA Polymerase III |
| Primary Target IC<sub>50</sub> | 27 µ |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 557404-5MG | 04055977268065 |
Documentation
InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem SDS
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InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 557404 |
References
| Reference overview |
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| Wu, L., et al. 2003. Euk. Cell 2, 256. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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