567022 Sigma-AldrichInSolution™ Simvastatin, Sodium Salt - Calbiochem
InSolution™ Simvastatin, Sodium Salt, 101314-97-0, is provided as a 10 mM in H₂O. It is the carboxylate form of Simvastatin that is active in whole cells and in cell-free preparations.
More>> InSolution™ Simvastatin, Sodium Salt, 101314-97-0, is provided as a 10 mM in H₂O. It is the carboxylate form of Simvastatin that is active in whole cells and in cell-free preparations. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: L-Type Calcium Channel Blocker VI
Recommended Products
Overview
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Key Specifications Table
| Empirical Formula |
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| C₂₅H₃₉O₆ •Na |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 567022-5MG | Glass bottle | 5 mg |
| Description | |
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| Overview | Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available. |
| Catalogue Number | 567022 |
| Brand Family | Calbiochem® |
| Synonyms | L-Type Calcium Channel Blocker VI |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O. |
| Hill Formula | C₂₅H₃₉O₆ •Na |
| Chemical formula | C₂₅H₃₉O₆ •Na |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 36/38 Irritating to eyes and skin. |
| S Phrase | S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 567022-5MG | 04055977267129 |
Documentation
InSolution™ Simvastatin, Sodium Salt - Calbiochem SDS
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InSolution™ Simvastatin, Sodium Salt - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 567022 |
References
| Reference overview |
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| Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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