Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

681676 InSolution™ Wortmannin - Calbiochem

Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase).

InSolution™ Wortmannin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MLCK Inhibitor II

View Products on Sigmaaldrich.com
681676
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₄O₈

Products

Catalog NumberPackaging Qty/Pack
681676-1MG Plastic ampoule 1 mg
Description
Catalogue Number681676
Brand Family Calbiochem®
SynonymsMLCK Inhibitor II
Application Data
References
ReferencesCross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.
Product Information
FormLiquid
FormulationA 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681675) in DMSO.
Hill FormulaC₂₃H₂₄O₈
Chemical formulaC₂₃H₂₄O₈
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 21/22-36/38

Harmful in contact with skin and if swallowed.
Irritating to eyes and skin.
S PhraseS: 24-26-36/37/39-45

Avoid contact with skin.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
681676-1MG 04055977225242

Documentation

InSolution™ Wortmannin - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Wortmannin - Calbiochem Certificates of Analysis

TitleLot Number
681676

References

Reference overview
Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-November-2008 JSW
SynonymsMLCK Inhibitor II
Application Data
DescriptionA fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) in purified preparations and cytosolic fractions (IC50 = 5 nM). Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (0.2-0.3 µM). Inhibits osteoclastic bone resorption. Inhibits other kinases, such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations 100-fold higher than that required for the inhibition of PI 3-kinase. Also blocks phospholipase D.
FormLiquid
FormulationA 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681675) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₄O₈
Purity≥95% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Harmful
Merck USA index14, 10053
ReferencesCross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.