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14-660M Itk Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617. For use in Kinase Assays.

Itk Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-660M
250 µg  Also available in 10 μg size (cat#14-660) and in bulk (cat# 14-660-K).
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Overview

Replacement Information
Description
Catalogue Number14-660M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionItk Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman Itk expressed by baculovirus in Sf21 cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThis gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Gene Symbol
  • ITK
  • LYK
  • PSCTK2
  • EMT
  • MGC126258
  • MGC126257
Protein TargetItk
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q08881 # Plays a role in T-cell proliferation and differentiation.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 620 amino acids; 71831 Da
SUBCELLULAR LOCATION: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity).
TISSUE SPECIFICITY: T-cell lines and natural killer cell lines.
SIMILARITY: SwissProt: Q08881 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight34kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of MBP.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-660) and in bulk (cat# 14-660-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-660M 04053252743894

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-660 Itk Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases