420202 Sigma-AldrichJMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem
The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: JHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1310809-17-6 | C₂₇H₂₉N₃O₆ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 420202-5MG | Glass bottle | 5 mg |
| Description | |
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| Overview | A substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203). |
| Catalogue Number | 420202 |
| Brand Family | Calbiochem® |
| Synonyms | JHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid |
| References | |
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| References | Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. |
| Product Information | |
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| CAS number | 1310809-17-6 |
| Form | Off-white powder |
| Hill Formula | C₂₇H₂₉N₃O₆ |
| Chemical formula | C₂₇H₂₉N₃O₆ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 420202-5MG | 04055977210767 |
Documentation
JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem SDS
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JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 420202 |
References
| Reference overview |
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| Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. |
Technical Info
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| White Paper - The Message in the Marks: Deciphering Cancer Epigenetics |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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