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422689 Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem

The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inward rectifier potassium channel blocker, ML133

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
185669-79-8C₁₉H₁₉NO

Products

Catalog NumberPackaging Qty/Pack
422689-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
Catalogue Number422689
Brand Family Calbiochem®
SynonymsInward rectifier potassium channel blocker, ML133
References
ReferencesLindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.
Product Information
CAS number185669-79-8
FormWhite solid
Hill FormulaC₁₉H₁₉NO
Chemical formulaC₁₉H₁₉NO
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
422689-5MG 04055977187229

Documentation

Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem Certificates of Analysis

TitleLot Number
422689

References

Reference overview
Lindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-April-2012 JSW
SynonymsInward rectifier potassium channel blocker, ML133
DescriptionA cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 > 300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number185669-79-8
Chemical formulaC₁₉H₁₉NO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml; clear, colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.