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489479 LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem

LSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM).

LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LSD Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV

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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₉N₃O₂ • 2HCl

Products

Catalog NumberPackaging Qty/Pack
489479-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.).
Catalogue Number489479
Brand Family Calbiochem®
SynonymsLSD Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV
References
ReferencesNeelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.
Product Information
FormYellow solid
Hill FormulaC₂₃H₂₉N₃O₂ • 2HCl
Chemical formulaC₂₃H₂₉N₃O₂ • 2HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationLSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM).
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
489479-10MG 04055977273403

Documentation

LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

LSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem Certificates of Analysis

TitleLot Number
489479

References

Reference overview
Neelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-March-2016 MJ
SynonymsLSD Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV
DescriptionA cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₉N₃O₂ • 2HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (2.5 mg/ml) or DMSO (2.5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesNeelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120.