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437627 Lipopolysaccharide, E. coli O111: B4 - Calbiochem

Lipopolysaccharide, E. coli O111: B4 stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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437627
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Overview

Replacement Information

Products

Catalog NumberPackaging Qty/Pack
437627-5MG Plastic ampoule 5 mg
Description
OverviewStimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
Catalogue Number437627
Brand Family Calbiochem®
References
ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.
Product Information
ATP CompetitiveN
FormLyophilized
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetInducible nitric oxide synthase
Physicochemical Information
Cell permeableN
ContaminantsProtein: ≤2.0%; nucleic acid: ≤2.5%
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSOJ0895400
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
437627-5MG 04055977187472

Documentation

Lipopolysaccharide, E. coli O111: B4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Lipopolysaccharide, E. coli O111: B4 - Calbiochem Certificates of Analysis

TitleLot Number
437627

References

Reference overview
Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2008 JSW
DescriptionEndotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxic shock, a profound life-threatening consequence of sepsis. More recently, these bacterial products have generated intense interest due to their pluropotential immunostimulatory activity as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cell activation by lipopolysaccharides produces a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor, and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
FormLyophilized
RTECSOJ0895400
ContaminantsProtein: ≤2.0%; nucleic acid: ≤2.5%
SolubilityH₂O (5 mg/ml) or 0.5% triethylamine (1 mg/ml). To achieve complete solubilization, heating solution to 37°C with intermittent vortexing or sonication may be necessary.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Harmful
ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.