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438185 Lovastatin - CAS 75330-75-5 - Calbiochem

Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

Lovastatin - CAS 75330-75-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mevinolin, MK-803, L-Type Calcium Channel Blocker IV

Primary Target: Activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
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438185
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
75330-75-5C₂₄H₃₆O₅

Products

Catalog NumberPackaging Qty/Pack
438185-25MG Plastic ampoule 25 mg
Description
OverviewAn anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Has been shown to block a series of biological events including: the activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes; the farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin); and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase through inhibition of proteasome. Has recently been shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and to block the transcription of type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
Catalogue Number438185
Brand Family Calbiochem®
SynonymsMevinolin, MK-803, L-Type Calcium Channel Blocker IV
References
ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.
Product Information
CAS number75330-75-5
ATP CompetitiveN
FormWhite to off-white powder
Hill FormulaC₂₄H₃₆O₅
Chemical formulaC₂₄H₃₆O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary TargetActivity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEK7907000
Safety Information
R PhraseR: 63

Possible risk of harm to the unborn child.
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
438185-25MG 04055977186956

Documentation

Lovastatin - CAS 75330-75-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Lovastatin - CAS 75330-75-5 - Calbiochem Certificates of Analysis

TitleLot Number
438185

References

Reference overview
Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
SynonymsMevinolin, MK-803, L-Type Calcium Channel Blocker IV
DescriptionAn anti-hypercholesterolemic agent and an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that blocks a series of biological events including: activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
FormWhite to off-white powder
Recommended reaction conditionsActivation Protocols: Liu, Li., et al. 1999. J. Biol. Chem. 274, 33334. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
CAS number75330-75-5
RTECSEK7907000
Chemical formulaC₂₄H₃₆O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 5586
ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.