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454870 MARK/Par-1 Activity Inhibitor, 39621 - CAS 895112-95-5 - Calbiochem

The MARK/Par-1 Activity Inhibitor, 39621 controls the biological activity of MARK/Par-1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor

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454870
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
895112-95-5C₂₁H₂₁N₃O₃S

Products

Catalog NumberPackaging Qty/Pack
454870-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50 = 3.6 µM; [ATP] = 100 µM). Shown to effectively block primary rat cortical neuron axon growth (5.7 µm/hr vs 32.5 µm/hr with or without 20 µM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10 µM).
Catalogue Number454870
Brand Family Calbiochem®
SynonymsN-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor
References
ReferencesTimm, T., et al. 2011. J. Biol. Chem. 286, 41711.
Product Information
CAS number895112-95-5
FormBeige solid
Hill FormulaC₂₁H₂₁N₃O₃S
Chemical formulaC₂₁H₂₁N₃O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
454870-10MG 04055977204261

Documentation

MARK/Par-1 Activity Inhibitor, 39621 - CAS 895112-95-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MARK/Par-1 Activity Inhibitor, 39621 - CAS 895112-95-5 - Calbiochem Certificates of Analysis

TitleLot Number
454870

References

Reference overview
Timm, T., et al. 2011. J. Biol. Chem. 286, 41711.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-September-2012 JSW
SynonymsN-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor
DescriptionA cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK inhibitor (IC50 = 3.6 µM; [ATP] = 100 µM) with much reduced or little activity against GSK-3β, SAD-kinase B/BRSK-1, MARKK/TAO-1, Cdc2/cycB, and p38/SAPK (30%, 20%, 11%, 4%, and 0% inhibition, respectively; [inhibitor] = 50 µM). Shown to effectively block primary rat cortical neuron axon growth (5.7 µm/hr vs 32.5 µm/hr with or without 20 µM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity due to microtubule network breakdown in CHO cells (10 µM).
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number895112-95-5
Chemical formulaC₂₁H₂₁N₃O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, yellow solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTimm, T., et al. 2011. J. Biol. Chem. 286, 41711.