373227 Sigma-AldrichMDM2 Inhibitor VII, MEL23 - CAS 642072-49-9 - Calbiochem
The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: MDM2-MDMX E3 Ligase Inhibitor, 3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 642072-49-9 | C₁₉H₂₂N₄O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 373227-10MG | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable tetrahydro-β-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100 µM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc. = 14 µM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3 (Cat. Nos. 444143 & 444151), MEL23 does not interfere with Mdm2-p53 interaction. |
| Catalogue Number | 373227 |
| Brand Family | Calbiochem® |
| Synonyms | MDM2-MDMX E3 Ligase Inhibitor, 3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione |
| References | |
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| References | Herman, A.G., et al. 2011. Cancer Discovery 1, 312. |
| Product Information | |
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| CAS number | 642072-49-9 |
| Form | Yellow solid |
| Hill Formula | C₁₉H₂₂N₄O₃ |
| Chemical formula | C₁₉H₂₂N₄O₃ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 373227-10MG | 04055977190991 |
Documentation
MDM2 Inhibitor VII, MEL23 - CAS 642072-49-9 - Calbiochem SDS
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MDM2 Inhibitor VII, MEL23 - CAS 642072-49-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 373227 |
References
| Reference overview |
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| Herman, A.G., et al. 2011. Cancer Discovery 1, 312. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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