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538437 MGAT2 Inhibitor, Cpd24d - Calbiochem

A cell-permeable, bioavailable, highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC₅₀ = 3.4 nM). Displays good microsomal stability.

MGAT2 Inhibitor, Cpd24d - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(N-(2,4-difluorophenyl)sulfamoyl)-7-(2-oxopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)indoline-1-carboxamide , Acyl CoA:monoacylglycerol acyltransferase 2 inhibitor, Cpd24d

Primary Target: MGAT2
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₆H₂₁F₅N₄O₄S

Products

Catalog NumberPackaging Qty/Pack
5.38437.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable, bioavailable, indoline derivative that acts as a highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC50 = 3.4 nM). Displays good microsomal stability and desirable pharmacokinetic properties (F = 52%; AUC 0 - 8 h = 842 ng/h/ml). Effectively suppresses the elevation of plasma triacylglyceride levels after olive oil challenge in C57BL/6J mice (10 - 30 mg/kg; p.o.).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538437
Brand Family Calbiochem®
Synonyms5-(N-(2,4-difluorophenyl)sulfamoyl)-7-(2-oxopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)indoline-1-carboxamide , Acyl CoA:monoacylglycerol acyltransferase 2 inhibitor, Cpd24d
References
ReferencesSato, K., et al. 2015. J. Med. Chem. 58, 3892.
Product Information
FormWhite solid
Hill FormulaC₂₆H₂₁F₅N₄O₄S
Chemical formulaC₂₆H₂₁F₅N₄O₄S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetMGAT2
Primary Target IC<sub>50</sub>3.4 nM for MGAT inhibition
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.38437.0001 04054839119606

Documentation

MGAT2 Inhibitor, Cpd24d - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Sato, K., et al. 2015. J. Med. Chem. 58, 3892.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-July-2017 JSW
Synonyms5-(N-(2,4-difluorophenyl)sulfamoyl)-7-(2-oxopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)indoline-1-carboxamide , Acyl CoA:monoacylglycerol acyltransferase 2 inhibitor, Cpd24d
DescriptionA cell-permeable, bioavailable, indoline derivative that acts as a highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC50 = 3.4 nM). Displays good microsomal stability and desirable pharmacokinetic properties (F = 52%; AUC 0 - 8 h = 842 ng/h/ml). Effectively suppresses the elevation of plasma triacylglyceride levels after olive oil challenge in C57BL/6J mice (10 - 30 mg/kg; p.o.).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₂₁F₅N₄O₄S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSato, K., et al. 2015. J. Med. Chem. 58, 3892.