Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

HNDG4MAG-36K MILLIPLEX MAP Human Neurodegenerative Disease Magnetic Bead Panel 4 - Neuroscience Multiplex Assay

The analytes available for this multiplex kit are: Amyloid β40, Amyloid β42, GDNF, sRAGE, S100B.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Multiplexing Detection Methods: Luminex xMAP Research Category: Neuroscience Research Sub-Category: Alzheimer's Disease, Nervous System
View Products on Sigmaaldrich.com
HNDG4MAG-36K
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
Amyloid β40 Amyloid β42 GDNF sRAGE S100B HMplexLuminex xMAP
Description
Catalogue NumberHNDG4MAG-36K
Trade Name
  • MILLIPLEX
DescriptionMILLIPLEX MAP Human Neurodegenerative Disease Magnetic Bead Panel 4 - Neuroscience Multiplex Assay
OverviewThe MILLIPLEX® MAP Human Neurodegenerative Magnetic Bead Panel 4 is to be used for the simultaneous quantification of the following 5 analytes in any combination in human cerebrospinal fluid (CSF): S100B, Amyloid β40 (Aβ1-40), Amyloid β42 (Aβ1-42), sRAGE, and GDNF. This kit is not validated for testing serum or cell culture supernatants.
Background InformationNeurodegenerative disease is a condition characterized by the deterioration of neurons or their myelin sheath over time in the brain and/or spinal cord. These neurons are responsible for such everyday activities as processing sensory information, making decisions, and controlling movement. Because these cells are not easily regenerated, excessive cumulative damage can lead to age-related diseases such as Alzheimer's and Parkinson's disease, as well as other conditions such as amyotrophic lateral sclerosis (ALS) and epilepsy. These disorders are devastating and expensive, both on a personal and global level, and as population demographics continue to change, a therapeutic solution is critical. Consequently, research is underway to identify biomarkers that will help scientists not only understand the pathogenesis of neurodegenerative disease, but also identify people with these disorders before the onset of symptoms and potentially provide new therapeutic tools.
References
Product Information
Detection methodLuminex xMAP
ConfigurationDesign your multiplex kit by choosing available analytes within this panel.
Precision, %
  • Intra-assay: < 8
  • Inter-assay: < 11
Panel TypeMAGNETIC Neuroscience
Quality LevelMQ200
Applications
ApplicationThe analytes available for this multiplex kit are: Amyloid β40, Amyloid β42, GDNF, sRAGE, S100B.
Key Applications
  • Multiplexing
Application Notes• This is an overnight assay.
• This assay requires 25 μL 1:3 diluted CSF per well.
Biological Information
Species Reactivity
  • Human
Analytes Available
  • Amyloid β40
  • Amyloid β42
  • GDNF
  • sRAGE
  • S100B
Assay PanelEverything you need in a single kit.
Cross ReactivityCross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Accuracy
  • 84% - 108%
Physicochemical Information
Sensitivity
  • Refer to kit protocol for sensitivities of individual analytes.
Standard Curve Range
  • Amyloid β40: 3 - 2,500 pg/mL
  • Amyloid β42: 27 - 20,000 pg/mL
  • GDNF: 7 - 5,000 pg/mL
  • sRAGE: 21 - 15,000 pg/mL
  • S100B: 14 - 10,000 pg/mL
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsRecommended storage for kit components is 2 - 8°C.
Packaging Information
Material Size96-well plate
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
HNDG4MAG-36K 04053252987571

Documentation

Protocols

Title
Protocol- HNDG4MAG-36K

MILLIPLEX MAP Human Neurodegenerative Disease Magnetic Bead Panel 4 - Neuroscience Multiplex Assay SDS

Title

Safety Data Sheet (SDS) 

References

Reference overviewPub Med ID
Plasma proteins predict conversion to dementia from prodromal disease.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, K³oszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S.
Alzheimers Dement. 2014 Nov;10(6):799- 807.e2  2014

25012867 25012867

Brochure

Title
A closer look at immunoassay platforms: Beyond fit for purpose
Custom Immunoassay Menu of Services
The Power of Biomarker Analysis

Technical Info

Title
96 well Template 2 Up
96 well Template Single
HNDG4MAG-36K xPonent Protocol Template Version 3.1
HNDG4MAG-36K xPonent Protocol Template Version Magpix
HNDG4MAG-36K xPonent Standard Template Version 3.1
HNDG4MAG-36K xPonent Standard Template Version Magpix
Quality Control Range Sheet- HNDG4-111 AND HNDG4-211
Quality Control Ranges: Milliplex Human Neurodegenerative Disease Magnetic Panel 4

Data Sheet

Title
Full Service Custom-built Assays

Posters

Title
MILLIPLEX MAP: Exercise, Signaling, and Your Brain
Toxicology in drug discovery and development: Biomarkers and model organisms