Qty	Catalog Number	Ordering Description	Qty/Pack	List Price
			96-Well Plate

Qty	Catalog Number	Ordering Description	Qty/Pack	List Price
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

PRCYASF-40K MilliporeMILLIPLEX® Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A SF, China only

Simultaneously analyze up to 48 cytokine, chemokine, and growth factor biomarkers with a bead-based multiplex assay using Luminex® xMAP® technology, in non-human primate cell culture samples.

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Description
Catalogue Number	PRCYASF-40K
Trade Name	MILLIPLEX
Description	MILLIPLEX® Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A SF, China only
Overview	MILLIPLEX® offers the broadest selection of analytes across a wide range of disease states and species. Once the analytes of interest have been identified, you can rely on the quality that we build into each kit to produce results you can trust. Each MILLIPLEX® panel and kit includes: • Quality controls (QCs) provided to qualify assay performance • Comparison of standard (calibrator) and QC lots to a reference lot to ensure lot-to-lot consistency • Detection antibody cocktails designed to yield consistent analyte profiles within panel
Background Information	“Cytokine” is a general term used for a diverse group of small proteins, peptides or glycoproteins secreted by lymphocytes, monocytes, macrophages and other cells that regulate immune responses, haematopoiesis and lymphocyte development. Cytokines include interleukins, interferons, chemokines and other signaling molecules. Growth factors are extracellular polypeptides that have a positive effect on cell growth and proliferation. They can stimulate growth in a variety of different cell types. Growth factors and cytokines are similar in structure and the way of action. Individual cytokines or growth factors are produced by multiple cell types. This is different from hormones, which tend to be made by specialized glands. Each cytokine or growth factor acts through its own receptor on target cells to generate signaling pathways, and as a consequence to regulate biological processes. Some intracellular signaling components are shared between cytokines and growth factors. Expression of cytokines or growth factors and their receptors is highly regulated. De-regulation may contribute to many diseases such as infectious disease, autoimmune and chronic inflammatory disease, cardiovascular disease, metabolic syndrome, neurological disorders and cancer. Cytokine and growth factor research plays a significant role in achieving a deeper understanding of the immune system and combating related diseases. As the most closely related species to humans, non-human primates are critical models for those studies. The MILLIPLEX® Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A Magnetic Bead Panel is a 48-plex kit to be used for the simultaneous quantification of any or all of the following analytes in tissue/cell lysate and culture supernatant samples: BCA-1, sCD137, sCD40L, Eotaxin, sFASL, FGF-2, Fractalkine, G-CSF, GM-CSF, Granzyme A, Granzyme B, IFNα2, IFNγ, IL-1α, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-15, IL-16, IL-17A, IL-17E, IL-18, IL-21, IL-22, IL-23, IL-28A, IL-31, IL-33, IP-10, I-TAC, MCP-1, MIG, MIP-1α, MIP-1β, MIP-3α, Perforin, RANTES, TGFα, TNFα, TNFβ, VEGF-A.

References

Product Information
Detection method	Luminex xMAP
Configuration	Design your multiplex kit by choosing available analytes within this panel.
Multiplex Ordering Requirements	For questions, contact Technical Service.
Panel Type	MAGNETIC Cytokines/Chemokines
Quality Level	MQ200

Applications
Application	Simultaneously analyze up to 48 cytokine, chemokine, and growth factor biomarkers with a bead-based multiplex assay using Luminex® xMAP® technology, in non-human primate cell culture samples.
Key Applications	Multiplexing
Application Notes	• This is an overnight or two-hour incubation assay. • This assay requires 25 µL of cell culture supernatant per well. • This kit may be used for the analysis of any or all of the Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A analytes in human tissue/cell lysate and culture supernatant samples.

Biological Information
Specificity	Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Species Reactivity	Non-human Primate
Analytes Available	G-CSF GM-CSF IFN-γ IL-1β IL-2 IL-4 IL-5 IL-6 IL-8 IL-10 IL-15 IL-18 MCP-1 MIP-1α MIP-1β TGF-α TNF-α BCA-1 sCD137 CD40 Ligand Eotaxin sFasL Fractalkine Granzyme A Granzyme B IFNα2 IFN-α IL-1Rα IL-7 IL-12(p70) IL-16 IL-17A IL-17E/IL-25 IL-21 IL-22 IL-23 IL-28A IL-31 IL-33 IP-10 I-TAC MIG MIP-3α Perforin RANTES TNFβ VEGF-A
Assay Panel	Everything you need in a single kit.
Cross Reactivity	There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel, except G-CSF had ~5% cross-reactivity with IL-1β.

Physicochemical Information
Sensitivity	Refer to kit protocol for sensitivities for individual cytokines/chemokines
Standard Curve Range	sCD40L: 48.83 - 200,000 pg/mL BCA-1, Eotaxin, GM-CSF, IL-1α, IL-2, IL-17A, IL-6, IP-10, I-TAC, MIP-3α, TNFβ: 1.22 - 5,000 pg/mL FGF-2: 61.04 - 250,000 pg/mL sCD137, Granzyme B, IL-1β: 0.98 - 4,000 pg/mL Fractalkine, IL-17E: 24.41 - 100,000 pg/mL IFNγ, IFNα2, IL-10, IL-22, VEGF-A: 2.44 - 10,000 pg/mL IL-16: 36.62 - 150,000 pg/mL sFASL, G-CSF, IL-1RA, IL-21, IL-7, MIG, TNFα: 4.88 - 20,000 pg/mL Granzyme A: 0.61 - 2,500 pg/mL IL-15, MIP-1β: 6.10 - 25,000 pg/mL IL-8: 0.05 - 200 pg/mL IL-23, IL-18: 19.53 - 80,000 pg/mL IL-12(p70), IL-28A, IL-31, IL-4: 12.21 - 50,000 pg/mL IL-33: 14.65 - 60,000 pg/mL IL-5: 2.93 - 12,000 pg/mL MCP-1: 3.05 - 12,500 pg/mL MIP-1α: 0.73 - 3,000 RANTES: 0.10 - 400 TGF-α: 0.49 - 2,000 Perforin: 97.66 - 400,000

Physicochemical Information

Sensitivity

Refer to kit protocol for sensitivities for individual cytokines/chemokines

Standard Curve Range

sCD40L: 48.83 - 200,000 pg/mL
BCA-1, Eotaxin, GM-CSF, IL-1α, IL-2, IL-17A, IL-6, IP-10, I-TAC, MIP-3α, TNFβ: 1.22 - 5,000 pg/mL
FGF-2: 61.04 - 250,000 pg/mL
sCD137, Granzyme B, IL-1β: 0.98 - 4,000 pg/mL
Fractalkine, IL-17E: 24.41 - 100,000 pg/mL
IFNγ, IFNα2, IL-10, IL-22, VEGF-A: 2.44 - 10,000 pg/mL
IL-16: 36.62 - 150,000 pg/mL
sFASL, G-CSF, IL-1RA, IL-21, IL-7, MIG, TNFα: 4.88 - 20,000 pg/mL
Granzyme A: 0.61 - 2,500 pg/mL
IL-15, MIP-1β: 6.10 - 25,000 pg/mL
IL-8: 0.05 - 200 pg/mL
IL-23, IL-18: 19.53 - 80,000 pg/mL
IL-12(p70), IL-28A, IL-31, IL-4: 12.21 - 50,000 pg/mL
IL-33: 14.65 - 60,000 pg/mL
IL-5: 2.93 - 12,000 pg/mL
MCP-1: 3.05 - 12,500 pg/mL
MIP-1α: 0.73 - 3,000
RANTES: 0.10 - 400
TGF-α: 0.49 - 2,000
Perforin: 97.66 - 400,000

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	• Recommended storage for kit components is 2 - 8°C. • For long-term storage, freeze reconstituted standards and controls at -20°C. Avoid multiple freeze/thaw cycles. • DO NOT FREEZE Antibody-Immobilized Beads, Detection Antibody, and Streptavidin-Phycoerythrin.

Packaging Information
Material Size	96-well plate

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
PRCYASF-40K	04065267238135

Documentation

MILLIPLEX® Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A SF, China only SDS

Title
Safety Data Sheet (SDS)

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PRCYASF-40K MilliporeMILLIPLEX® Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A SF, China only

Simultaneously analyze up to 48 cytokine, chemokine, and growth factor biomarkers with a bead-based multiplex assay using Luminex® xMAP® technology, in non-human primate cell culture samples.

Recommended Products

Overview

Special Offers

Documentation

MILLIPLEX® Non-Human Primate Cytokine/Chemokine/Growth Factor Panel A SF, China only SDS

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