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475864 MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem

MK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1186648-22-5C₂₁H₁₆N₄O • H₂O

Products

Catalog NumberPackaging Qty/Pack
475864-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
Catalogue Number475864
Brand Family Calbiochem®
Synonyms2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
References
ReferencesAnderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
Product Information
CAS number1186648-22-5
FormPale yellow solid
Hill FormulaC₂₁H₁₆N₄O • H₂O
Chemical formulaC₂₁H₁₆N₄O • H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationMK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
475864-5MG 04055977203400

Documentation

MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem Certificates of Analysis

TitleLot Number
475864

References

Reference overview
Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.

Brochure

Title
MAPK Pathway Poster ( 750 KB )
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
DescriptionA cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1186648-22-5
Chemical formulaC₂₁H₁₆N₄O • H₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAnderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.