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444283 MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem

The MMP-13 Inhibitor, also referenced under CAS 544678-85-5, controls the biological activity of MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)

Primary Target: MMP-13 activity
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
544678-85-5C₂₂H₂₀F₂N₄O₂

Products

Catalog NumberPackaging Qty/Pack
444283-1MG Plastic ampoule 1 mg
Description
OverviewA pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
Catalogue Number444283
Brand Family Calbiochem®
SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
References
ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.
Product Information
CAS number544678-85-5
ATP CompetitiveN
FormLight yellow solid
Hill FormulaC₂₂H₂₀F₂N₄O₂
Chemical formulaC₂₂H₂₀F₂N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-13 activity
Primary Target IC<sub>50</sub>8 nM against MMP-13
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
444283-1MG 04055977186000

Documentation

MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem Certificates of Analysis

TitleLot Number
444283

References

Reference overview
Engel, C.K., et al. 2005. Chem. Biol. 12, 181.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-August-2008 RFH
SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
DescriptionA potent inhibitor of MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number544678-85-5
Chemical formulaC₂₂H₂₀F₂N₄O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml). Further dilute in buffer immediately prior to use.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.