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444252 MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem

The MMP-9/MMP-13 Inhibitor I, also referenced under CAS 204140-01-2, controls the biological activity of MMP-9/MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide

Primary Target: MMP-9
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
204140-01-2C₂₅H₂₅N₃O₆S

Products

Catalog NumberPackaging Qty/Pack
444252-1MG Plastic ampoule 1 mg
Description
OverviewA piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
Catalogue Number444252
Brand Family Calbiochem®
SynonymsN-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
References
ReferencesCheng, M., et al. 2000. J. Med. Chem. 43, 369.
Product Information
CAS number204140-01-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₅H₂₅N₃O₆S
Chemical formulaC₂₅H₂₅N₃O₆S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-9
Primary Target IC<sub>50</sub>900 pM against both MMP-9 and MMP-13
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
444252-1MG 04055977186529

Documentation

MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem Certificates of Analysis

TitleLot Number
444252

References

Reference overview
Cheng, M., et al. 2000. J. Med. Chem. 43, 369.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsN-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
DescriptionA cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number204140-01-2
Chemical formulaC₂₅H₂₅N₃O₆S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCheng, M., et al. 2000. J. Med. Chem. 43, 369.