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534352 MNK Inhibitor IV, Mnk-I1 - Calbiochem

MNK Inhibitor IV, Mnk-I1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MNK1 Inhibitor, Mnk-I1

Primary Target: MNK
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₂₇F₂N₅O₂S

Products

Catalog NumberPackaging Qty/Pack
5.34352.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable thieno[2,3-d]pyrimidine compound that acts as a selective inhibitor of MAP kinase-interacting kinases 1 and 2 (Mnk1 and 2: IC50 = 23 and 16 nM for MNK1 and MNK2, respectively). Displays much reduced activity against several other protein kinases and does not affect the phosphorylation of ERK, Akt, mTORC1, and ribosomal S6 kinase. Shown to strongly inhibit eIF4E phosphorylation (~1 µM) and abolished the activity completely at higher concentration in MDA-MB-231 and SSC25 cancer cell (~ 1 µM). Shown to be much more effective Mnk inhibitor than CGP57380 (Cat. No. 454861). Reported to inhibit the migration of mouse embryonic fibroblasts and MDA-MB-231 and SCC25 cells, but does not affect their viability and proliferation.
Catalogue Number534352
Brand Family Calbiochem®
SynonymsMNK1 Inhibitor, Mnk-I1
References
ReferencesBeggs, J.E., et al. 2015. Biochem. J. 467, 63.
Product Information
FormLight beige solid
Hill FormulaC₂₂H₂₇F₂N₅O₂S
Chemical formulaC₂₂H₂₇F₂N₅O₂S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetMNK
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.34352.0001 04054839117251

Documentation

MNK Inhibitor IV, Mnk-I1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Beggs, J.E., et al. 2015. Biochem. J. 467, 63.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-July-2017 JSW
SynonymsMNK1 Inhibitor, Mnk-I1
DescriptionA cell-permeable thieno[2,3-d]pyrimidine compound that acts as a selective inhibitor of MAP kinase-interacting kinases 1 and 2 (Mnk1 and 2: IC50 = 23 and 16 nM for MNK1 and MNK2, respectively). Displays much reduced activity against several other protein kinases and does not affect the phosphorylation of ERK, Akt, mTORC1, and ribosomal S6 kinase. Shown to strongly inhibit eIF4E phosphorylation (~1 µM) and abolished the activity completely at higher concentration in MDA-MB-231 and SSC25 cancer cell (~ 1 µM). Shown to be much more effective Mnk inhibitor than CGP57380 (Cat. No. 454861). Reported to inhibit the migration of mouse embryonic fibroblasts and MDA-MB-231 and SCC25 cells, but does not affect their viability and proliferation.
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₂₇F₂N₅O₂S
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBeggs, J.E., et al. 2015. Biochem. J. 467, 63.