444130 Sigma-AldrichMcl-1 Inhibitor, MIM1 - Calbiochem
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Overview
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Products
| Catalog Number | Packaging | Qty/Pack | |
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| 444130-25MG | Glass bottle | 25 mg |
| Description | |
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| Overview | A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF. |
| Catalogue Number | 444130 |
| Brand Family | Calbiochem® |
| Synonyms | 4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1 |
| References | |
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| References | Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175. |
| Product Information | |
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| Form | Yellow powder |
| Hill Formula | C₁₇H₂₁N₃O₃S |
| Chemical formula | C₁₇H₂₁N₃O₃S |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | Mcl-1 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 444130-25MG | 04055977205428 |
Documentation
Mcl-1 Inhibitor, MIM1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 444130 |
References
| Reference overview |
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| Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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