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FCMAB195F Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12

This Milli-Mark Anti-CD41-FITC Antibody, clone 5B12 is validated for use in FC for the detection of CD41.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P08514
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FCMAB195F
100 tests  
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Key Specifications Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB195F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-CD41-FITC Antibody, clone 5B12
Alternate Names
  • Integrin alpha-IIb
  • Platelet membrane glycoprotein IIb
  • GPalpha IIb
  • GPIIb
Background InformationCD41 is the α-subunit of the CD41/CD61 complex (GPIIb-IIIa), a calcium-dependent, non-covalently associated heterodimer. CD41 is a 135 kDa molecule, consisting of 2 peptides: a 120 kDa α chain and a 23 kDa β chain. The α chain and the β chain are linked by a single disulphide bond. The α chain contains four calcium-binding sites and is entirely extracellular, while the β-chain has extracellular, transmembrane, and cytoplasmic domains (Sun, 1997). The CD41/CD61 complex appears early in megakaryocyte maturation (Vinci, 1984). Anti-CD41, 5B12, was included in the Fifth International Workshop and Conference on Human Leukocyte Differentiation Antigens and studies by a number of laboratories confirmed its reactivity with CD41 (Honda, 1995).
References
Product Information
FormatFITC
Control
  • TF-1 cells
PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Quality LevelMQ100
Applications
ApplicationThis Milli-Mark Anti-CD41-FITC Antibody, clone 5B12 is validated for use in FC for the detection of CD41.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenNormal human platelets
Clone5B12
HostMouse
SpecificityAntibody recognizes Human CD41 antigen.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Molecular Weight135 kDa (Sun, 1997)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using TF-1 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
FCMAB195F 04053252480218

Documentation

Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12 SDS

Title

Safety Data Sheet (SDS) 

Milli-Mark™ Anti-CD41-FITC Antibody, clone 5B12 Certificates of Analysis

TitleLot Number
Milli-Mark Anti-CD41-FITC, clone 5B12 - 1985162 1985162
Milli-Mark Anti-CD41-FITC, clone 5B12 - 2051918 2051918
Milli-Mark Anti-CD41-FITC, clone 5B12 - 2106923 2106923
Milli-Mark Anti-CD41-FITC, clone 5B12 - 2196072 2196072
Milli-Mark Anti-CD41-FITC, clone 5B12 - NRG1779488 NRG1779488
Milli-Mark™ Anti-CD41-FITC, -2522234 2522234
Milli-Mark™ Anti-CD41-FITC, -2762248 2762248
Milli-Mark™ Anti-CD41-FITC, -2816756 2816756
Milli-Mark™ Anti-CD41-FITC, clone 5B12 - 2491244 2491244
Milli-Mark™ Anti-CD41-FITC, clone 5B12 - 3199187 3199187
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