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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

EZML-82BK Sigma-AldrichMouse Leptin ELISA- Space Saver (Bulk) Packaging

This Mouse Leptin ELISA is used to measure & quantify Leptin levels in Metabolism & Endocrine & Neuroscience research.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Key Applications: ELISA Detection Methods: Fluorescent, Colorimetric Research Category: Metabolism Research Sub-Category: Obesity, Metabolic Disorders

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Overview

Replacement Information

Key Specifications Table

Analytes Available	Species Reactivity	Key Applications	Detection Methods
Leptin	M	ELISA	Fluorescent Colorimetric

Description
Catalogue Number	EZML-82BK
Description	Mouse Leptin ELISA- Space Saver (Bulk) Packaging
Background Information	Leptin is synthesized in adipocytes as a 16 kDa molecule and the circulating level is directly proportional to the total amount of fat in the body.

References

Product Information
Detection method	Fluorescent Colorimetric
Precision, %	Inter-assay: 3.0–4.6 Intra-assay: 1.1–1.8
Quality Level	MQ200

Applications
Application	This Mouse Leptin ELISA is used to measure & quantify Leptin levels in Metabolism & Endocrine & Neuroscience research.
Key Applications	ELISA
Application Notes	Room temperature, 4 hour assay 10 µL sample size

Biological Information
Species Reactivity	Mouse
Analytes Available	Leptin
Entrez Gene Summary	This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
UniProt Number	P41160 P41159
UniProt Summary	FUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. SIZE: 167 amino acids; 18641 Da SUBUNIT: Interacts with SIGLEC6. SUBCELLULAR LOCATION: Secreted. DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665]. SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
Accuracy	87–100%

Physicochemical Information
Sensitivity	0.05 ng/mL
Linearity of Dilution	100–111%
Standard Curve Range	0.2–30 ng/mL

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	For research use only. Not for use in diagnostic procedures.

Storage and Shipping Information

Packaging Information
Material Size	96-well strip plate

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
EZML-82BK	04053252437038

Documentation

Mouse Leptin ELISA- Space Saver (Bulk) Packaging SDS

Title
Safety Data Sheet (SDS)

Related Products & Applications

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