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475951 MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem

A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: S-(3,4-Dichlorobenzyl)isothiourea, HCl

Primary Target: MreB
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
22816-60-0C₈H₈Cl₂N₂S • HCl

Products

Catalog NumberPackaging Qty/Pack
475951-25MG Plastic ampoule 25 mg
Description
OverviewA cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
Catalogue Number475951
Brand Family Calbiochem®
SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
References
ReferencesGitai, Z., et al. 2005. Cell 120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
Product Information
CAS number22816-60-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₈Cl₂N₂S • HCl
Chemical formulaC₈H₈Cl₂N₂S • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMreB
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
475951-25MG 07790788050580

Documentation

MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem Certificates of Analysis

TitleLot Number
475951

References

Reference overview
Gitai, Z., et al. 2005. Cell 120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
DescriptionA cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number22816-60-0
Chemical formulaC₈H₈Cl₂N₂S • HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or H₂O (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
Toxicity Standard Handling
ReferencesGitai, Z., et al. 2005. Cell 120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.