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23-054M MuRF1 Protein, active, 250 µg

Active, full length, recombinant human MuRF1. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

MuRF1 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays
23-054M
250 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

Key ApplicationsSpeciesCascade Component
Enzyme AssaysHuman E3
Description
Catalogue Number23-054M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMuRF1 Protein, active, 250 µg
Alternate Names
  • E3 ubiquitin-protein ligase TRIM63
  • Iris RING finger protein (IRF)
  • Muscle-specific RING finger protein 1
  • RING finger protein 28 (RNF28)
  • Striated muscle RING zinc finger protein (SMRZ)
Background InformationMuscle atrophy is a debilitating and life threatening disorder. It is associated with a number of diseases including cancer, diabetes, chronic obstructive pulmonary disease and AIDS and is a natural consequence of inactivity and aging. MuRF1 is an E3 ubiquitin ligase which has been implicated as a component of atrophy-associated proteolysis. It contains an amino terminal RING finger that mediates ubiquitin transfer along with a zinc finger and two coiled-coil domains in its central region. It is up-regulated in a number of different models of atrophy and interacts with numerous myofibrillar proteins as well as Cardiac Troponin I and Creatine Kinase. Deletion of MuRF1 in mice has been shown to inhibit skeletal muscle atrophy suggesting that it may be an important drug target for the prevention of muscle wasting.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, full length, recombinant human MuRF1. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentE3
Entrez Gene Number
Purification MethodPurified using glutathione sepharose.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size250 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
23-054M 04053252444043

Related Products & Applications

Alternative Packsize

Catalog Number Description
23-054 MuRF1 Protein, active, 10 µg

Product Families

Ubiquitin Proteasome System: Enzymes and Substrates

Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
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Categories

Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases