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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

Primary Target: translocation of the NF-κB active complex into the nucleus
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481480
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

Products

Catalog NumberPackaging Qty/Pack
481480-1MG Plastic ampoule 1 mg
481480-500UG Plastic ampoule 500 μg
Description
OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
Catalogue Number481480
Brand Family Calbiochem®
SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
References
ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary Targettranslocation of the NF-κB active complex into the nucleus
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide ContentY
Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
481480-1MG 04055977183771
481480-500UG 04055977183788

Documentation

NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem Certificates of Analysis

TitleLot Number
481480

References

Reference overview
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

Citations

Title
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-March-2008 JSW
    SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
    DescriptionContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.
    FormLyophilized
    FormulationSupplied as a trifluoroacetate salt.
    Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
    Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
    Purity≥97% by HPLC
    SolubilityH₂O (5 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
    Toxicity Standard Handling
    ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
    Citation
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•