480402 Sigma-AldrichNFAT Inhibitor - CAS 249537-73-3 - Calbiochem
The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: MAGPHPVIVITGPHEE
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
|---|---|
| 249537-73-3 | C₇₅H₁₁₈N₂₀O₂₂S |
Products
| Catalog Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 480402-500UG | Plastic ampoule | 500 μg |
| Description | |
|---|---|
| Overview | A highly selective NFAT (Nuclear Factor of Activated T-cells) inhibitor that interferes with calcineurin-NFAT interaction without affecting calcineurin (Cat. No. 539568) phosphatase activity. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT. |
| Catalogue Number | 480402 |
| Brand Family | Calbiochem® |
| Synonyms | MAGPHPVIVITGPHEE |
| References | |
|---|---|
| References | Noguchi, H., et al. 2004. Nat. Med. 10, 305. Kiani, A., et al. 2001. Blood 98, 1480. Aramburu, J., et al. 1999. Science 285, 2129. |
| Product Information | |
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| CAS number | 249537-73-3 |
| ATP Competitive | N |
| Form | Lyophilized solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₇₅H₁₁₈N₂₀O₂₂S |
| Chemical formula | C₇₅H₁₁₈N₂₀O₂₂S |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NFAT (Nuclear Factor of Activated T-cells) |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Peptide Sequence | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 480402-500UG | 07790788050658 |
Documentation
NFAT Inhibitor - CAS 249537-73-3 - Calbiochem SDS
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NFAT Inhibitor - CAS 249537-73-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 480402 |
References
| Reference overview |
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| Noguchi, H., et al. 2004. Nat. Med. 10, 305. Kiani, A., et al. 2001. Blood 98, 1480. Aramburu, J., et al. 1999. Science 285, 2129. |