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480747 Neurogenesis Inducer V, KHS101 - CAS 1262770-73-9 - Calbiochem

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

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480747
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Overview

Replacement Information

Products

Catalog NumberPackaging Qty/Pack
480747-10MG Glass bottle 10 mg
Description
OverviewA blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.
Catalogue Number480747
Brand Family Calbiochem®
SynonymsN⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine
References
ReferencesWurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16542
Product Information
CAS number1262770-73-9
FormSticky yellow resin
Hill FormulaC₁₈H₂₁N₅S
Chemical formulaC₁₈H₂₁N₅S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
480747-10MG 04055977201468

Documentation

Neurogenesis Inducer V, KHS101 - CAS 1262770-73-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Neurogenesis Inducer V, KHS101 - CAS 1262770-73-9 - Calbiochem Certificates of Analysis

TitleLot Number
480747

References

Reference overview
Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16542
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-October-2012 JSW
SynonymsN⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine
DescriptionA blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.
FormSticky yellow resin
Intert gas (Yes/No) Packaged under inert gas
CAS number1262770-73-9
Chemical formulaC₁₈H₂₁N₅S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16542