495620 Sigma-AldrichOlomoucine - CAS 101622-51-9 - Calbiochem
A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
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Synonyms: Olomoucine
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 101622-51-9 | C₁₅H₁₈N₆O |
Products
| Catalog Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 495620-1MG | Plastic ampoule | 1 mg | |
| 495620-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available. |
| Catalogue Number | 495620 |
| Brand Family | Calbiochem® |
| Synonyms | Olomoucine |
| Product Information | |
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| CAS number | 101622-51-9 |
| ATP Competitive | Y |
| Form | Crystalline solid |
| Hill Formula | C₁₅H₁₈N₆O |
| Chemical formula | C₁₅H₁₈N₆O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 495620-1MG | 04055977199789 |
| 495620-5MG | 04055977199796 |
Documentation
Olomoucine - CAS 101622-51-9 - Calbiochem SDS
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Olomoucine - CAS 101622-51-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 495620 |
References
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| Abraham, R.T., et al. 1995. Biol. Cell 83, 105. Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715. Glab, N., et al. 1994. FEBS Lett. 353, 207. Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771. |
Brochure
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| MAPK Pathway Poster ( 750 KB ) |