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538094 P18IN011 - CAS 77408-67-4 - Calbiochem

A cell-permeable, selective & direct blocker of p18-Cdk6 interaction. Inhibits p18INK4C protein activity & favors HSCs self-renewal by ~4.2-fold.

P18IN011 - CAS 77408-67-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor

Primary Target: p18
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
77408-67-4C₁₅H₁₂N₂O₅S

Products

Catalog NumberPackaging Qty/Pack
5.38094.0001 Glass bottle 25 mg
Description
OverviewA cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED50 of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538094
Brand Family Calbiochem®
Synonyms1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor
DescriptionP18IN011
References
ReferencesGao, Y., et al. 2015. Nat. Commun. 6, 6328.
Product Information
CAS number77408-67-4
FormWhite solid
Hill FormulaC₁₅H₁₂N₂O₅S
Chemical formulaC₁₅H₁₂N₂O₅S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetp18
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.38094.0001 04054839059285

Documentation

P18IN011 - CAS 77408-67-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Gao, Y., et al. 2015. Nat. Commun. 6, 6328.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-August-2016 JSW
Synonyms1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor
DescriptionA cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED50 of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number77408-67-4
Chemical formulaC₁₅H₁₂N₂O₅S
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGao, Y., et al. 2015. Nat. Commun. 6, 6328.