234490 Sigma-AldrichPD 153035 - CAS 153436-54-5 - Calbiochem
An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM).
More>> An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM). Less<<Synonyms: AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
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Overview
Key Specifications Table
CAS # | Empirical Formula |
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153436-54-5 | C₁₆H₁₄BrN₃O₂ |
Products
Catalog Number | Packaging | Qty/Pack | |
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234490-1MG | Plastic ampoule | 1 mg |
Description | |
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Overview | An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available. |
Catalogue Number | 234490 |
Brand Family | Calbiochem® |
Synonyms | AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32 |
References | |
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References | Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093. |
Product Information | |
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CAS number | 153436-54-5 |
ATP Competitive | Y |
Declaration | Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266. |
Form | White solid |
Hill Formula | C₁₆H₁₄BrN₃O₂ |
Chemical formula | C₁₆H₁₄BrN₃O₂ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | EGFR |
Primary Target IC<sub>50</sub> | 25 pM |
Primary Target K<sub>i</sub> | 6 pM against epidermal growth factor receptor (EGFR) |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Global Trade Item Number | |
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Catalog Number | GTIN |
234490-1MG | 04055977200256 |