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234490 PD 153035 - CAS 153436-54-5 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
153436-54-5C₁₆H₁₄BrN₃O₂

Products

Catalog NumberPackaging Qty/Pack
234490-1MG Plastic ampoule 1 mg
Description
OverviewAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
Catalogue Number234490
Brand Family Calbiochem®
SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
References
ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Fry, D.W., et al. 1994. Science 265, 1093.
Product Information
CAS number153436-54-5
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
FormWhite solid
Hill FormulaC₁₆H₁₄BrN₃O₂
Chemical formulaC₁₆H₁₄BrN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>25 pM
Primary Target K<sub>i</sub>6 pM against epidermal growth factor receptor (EGFR)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalog Number GTIN
234490-1MG 04055977200256