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513030 PD 169316 - CAS 152121-53-4 - Calbiochem

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

PD 169316 - CAS 152121-53-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

Primary Target: p38 MAP kinase
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
152121-53-4C₂₀H₁₃FN₄O₂

Products

Catalog NumberPackaging Qty/Pack
513030-1MG Plastic ampoule 1 mg
Description
OverviewA potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
Catalogue Number513030
Brand Family Calbiochem®
Synonyms4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
References
ReferencesNath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.
Product Information
CAS number152121-53-4
ATP CompetitiveY
FormOrange-yellow solid
Hill FormulaC₂₀H₁₃FN₄O₂
Chemical formulaC₂₀H₁₃FN₄O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp38 MAP kinase
Primary Target IC<sub>50</sub>89 nM against p38 MAP kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
513030-1MG 04055977198621

Documentation

PD 169316 - CAS 152121-53-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PD 169316 - CAS 152121-53-4 - Calbiochem Certificates of Analysis

TitleLot Number
513030

References

Reference overview
Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

Brochure

Title
MAPK Pathway Poster ( 750 KB )
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2010 RFH
Synonyms4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
DescriptionA potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
FormOrange-yellow solid
CAS number152121-53-4
Chemical formulaC₂₀H₁₃FN₄O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesNath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.