521231 Sigma-AldrichPDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem
The PDGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 249762-74-1, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The PDGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 249762-74-1, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 249762-74-1 | C₂₁H₁₈N₂O₃ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 521231-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | A cell-permeable bis(1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC50 = 1.1 µM in Swiss 3T3 cells for PDGFR). Also potently inhibits Flt3 (Fms-like tyrosine kinase 3) activity (IC50 = 6.2 µM for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells). Sensitizes 32D cells to radiation-induced apoptosis and inhibits proliferation of TEL-Flt3-transfected BA/F3 cells (IC50 < 300 nM). May also serve as a prodrug form of the Platelet Derived Growth Factor Receptor Tyrosine Kinase Inhibitor I (Cat. No. 521230) in cells. |
| Catalogue Number | 521231 |
| Brand Family | Calbiochem® |
| Synonyms | (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476 |
| References | |
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| References | Mahboobi, S., et al. 2002. J. Med. Chem. 45, 1002. Teller, S., et al. 2002. Leukemia 16, 1528. |
| Product Information | |
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| CAS number | 249762-74-1 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₂₁H₁₈N₂O₃ |
| Chemical formula | C₂₁H₁₈N₂O₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Cell permeable | Y |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 521231-1MG | 04055977271355 |
Documentation
PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem SDS
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PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 521231 |
References
| Reference overview |
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| Mahboobi, S., et al. 2002. J. Med. Chem. 45, 1002. Teller, S., et al. 2002. Leukemia 16, 1528. |