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14-604M PI3 Kinase (p110δ/p85α) Protein, active, 250 µg

Active complex of N-terminal His6-tagged recombinant, full-length, human p110δ & untagged, recombinant, full length, human p85α. For use in Kinase Assays.

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14-604M
250 µg  Also available in 10 μg size (cat#14-604) and in bulk (cat# 14-604-K).
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Overview

Replacement Information
Description
Catalogue Number14-604M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPI3 Kinase (p110δ/p85α) Protein, active, 250 µg
OverviewComplex of N-terminal His6-tagged recombinant, full-length, human p110δ and untagged, recombinant, full length, human p85α
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive complex of N-terminal His6-tagged recombinant, full-length, human p110δ & untagged, recombinant, full length, human p85α. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceCoexpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryPhosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM]
Gene Symbol
  • PIK3CD
  • p110d
  • PI3K
  • p110D
  • p110delta
Protein TargetPI3Kδ/p85α
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyPI3K/PI4K
UniProt Number
UniProt SummarySIZE: 1044 amino acids; 119479 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS (By similarity).
TISSUE SPECIFICITY: Expressed predominantly in leukocytes.
PTM: Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.
SIMILARITY: SwissProt: O00329 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular WeightP110δ (121.6kDa) & p85α (83.7kDa)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by the PIProfiler™
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-604) and in bulk (cat# 14-604-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-604M 04053252670794

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-604 PI3 Kinase (p110δ/p85α) Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases