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533657 PI4KIIIβ Inhibitor, BF738735 - CAS 1436383-95-7 - Calbiochem

A cell-permeable, potent and reversible PI4KIIIb inhibitor that displays antiviral property. Targets OSBP and inhibit cholesterol shuttling to replication organelles.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735

Primary Target: PI4KIII&beta
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1436383-95-7C₂₁H₁₉FN₄O₃S

Products

Catalog NumberPackaging Qty/Pack
5.33657.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 > 10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
Catalogue Number533657
Brand Family Calbiochem®
Synonyms2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
DescriptionPI4KIIIβ Inhibitor, BF738735
References
ReferencesStrating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.
Product Information
CAS number1436383-95-7
FormLight grey powder
Hill FormulaC₂₁H₁₉FN₄O₃S
Chemical formulaC₂₁H₁₉FN₄O₃S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI4KIII&beta
Primary Target IC<sub>50</sub>5.7 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.33657.0001 04055977286588

Documentation

PI4KIIIβ Inhibitor, BF738735 - CAS 1436383-95-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Strating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2016 JSW
Synonyms2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
DescriptionA cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 > 10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
FormLight grey powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1436383-95-7
Chemical formulaC₂₁H₁₉FN₄O₃S
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesStrating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.