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14-506M PKD2 Recombinant Human Protein, Active, 250 µg

Active, N-terminal His6 tagged, recombinant, full length, human PKD2, for use in Kinase Assays.

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14-506M
250 µg  Also available in 10 μg size (cat#14-506) and in bulk (cat# 14-506-K).
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Overview

Replacement Information
Description
Catalogue Number14-506M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPKD2 Recombinant Human Protein, Active, 250 µg
OverviewN-terminal His6 tagged, recombinant, full length, human PKD2
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal His6 tagged, recombinant, full length, human PKD2, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed in sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Symbol
  • PRKD2
  • DKFZP586E0820
  • PKD2
  • nPKC-D2
  • HSPC187
Protein TargetPKD2
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyCAMK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9BZL6 # Calcium-independent, phospholipid-dependent, serine- and threonine-specific protein kinase.
SIZE: 878 amino acids; 96722 Da
TISSUE SPECIFICITY: Widely expressed.
PTM: Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase.
SIMILARITY: SwissProt: Q9BZL6 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 PH domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
Molecular Weight100kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-506) and in bulk (cat# 14-506-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-506M 04053252287596

Related Products & Applications

Alternative Packsize

Catalog Number Description
14-506 PKD2 Recombinant Human Protein, Active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases