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550602 PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem

PKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1186654-00-1C₁₈H₁₈F₂N₂O₆S₂

Products

Catalog NumberPackaging Qty/Pack
550602-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
Catalogue Number550602
Brand Family Calbiochem®
SynonymsPyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
References
ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
Product Information
CAS number1186654-00-1
FormWhite powder
Hill FormulaC₁₈H₁₈F₂N₂O₆S₂
Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
550602-10MG 04055977268874

Documentation

PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem Certificates of Analysis

TitleLot Number
550602

References

Reference overview
Anastasiou, D., et al. 2011. Science 334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2012 JSW
SynonymsPyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
DescriptionA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1186654-00-1
Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.