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14-572 PLK3 Protein, active, 10 µg

Active, N-terminal His6-tagged recombinant human Plk3, residues 19-301, for use in Kinase Assays.

PLK3 Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-572
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-572M when ordering the 250 µg size.
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Overview

Replacement Information
Description
Catalogue Number14-572
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPLK3 Protein, active, 10 µg
OverviewN-terminal His6-tagged recombinant human Plk3, residues 19-301
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal His6-tagged recombinant human Plk3, residues 19-301, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryCytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.
Gene Symbol
  • PLK3
  • CNK
  • PLK-3
  • FNK
  • PRK
Protein TargetPLK3
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyAGC
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9H4B4 # Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein.
SIZE: 646 amino acids; 71629 Da
SUBUNIT: Binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
PTM: Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis (By similarity).
SIMILARITY: SwissProt: Q9H4B4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. & Contains 2 POLO box domains. & Contains 1 protein kinase domain.
Molecular Weight36kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of Casein
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size10 µg
Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-572M when ordering the 250 µg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
14-572 04053252335273