529573 Sigma-AldrichPP2 - CAS 172889-27-9 - Calbiochem
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).
More>> PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). Less<<PP2 - CAS 172889-27-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 172889-27-9 | C₁₅H₁₆ClN₅ |
Products
| Catalog Number | Packaging | Qty/Pack | |
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| 529573-1MG | Plastic ampoule | 1 mg | |
| 529573-5MG | Glass bottle | 5 mg |
| Description | |
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| Overview | A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available. |
| Catalogue Number | 529573 |
| Brand Family | Calbiochem® |
| Synonyms | AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine |
| References | |
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| References | Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
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| CAS number | 172889-27-9 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₅H₁₆ClN₅ |
| Chemical formula | C₁₅H₁₆ClN₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | N |
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| Safety Information according to GHS |
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| Safety Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 529573-1MG | 07790788051198 |
| 529573-5MG | 04055977269802 |
Documentation
PP2 - CAS 172889-27-9 - Calbiochem SDS
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PP2 - CAS 172889-27-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 529573 |
References
| Reference overview |
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| Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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