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520222 PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem

PPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Thrombin
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520222
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
82188-90-7C₂₁H₃₃N₆O₃•2HCl

Products

Catalog NumberPackaging Qty/Pack
520222-25MG Plastic ampoule 25 mg
520222-5MG Plastic ampoule 5 mg
Description
OverviewExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H2O (Cat. No. 508773).
Catalogue Number520222
Brand Family Calbiochem®
References
ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
Product Information
CAS number82188-90-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₁H₃₃N₆O₃•2HCl
Chemical formulaC₂₁H₃₃N₆O₃•2HCl
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationPPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.
Biological Information
Primary TargetThrombin
Primary Target IC<sub>50</sub>Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
Purity≥80% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
520222-25MG 04055977271294
520222-5MG 07790788051020

Documentation

PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem Certificates of Analysis

TitleLot Number
520222

References

Reference overview
Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

Citations

Title
  • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-May-2013 JSW
    DescriptionExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.
    FormWhite solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number82188-90-7
    Chemical formulaC₂₁H₃₃N₆O₃•2HCl
    Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
    Purity≥80% by HPLC
    SolubilityH₂O (100 mg/ml)
    Storage Protect from moisture
    Protect from light
    +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
    Toxicity Standard Handling
    Merck USA index14, 7699
    ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
    Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
    Arni, R.K., et al. 1993. Biochemistry 32, 4727.
    Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
    Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
    Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
    Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
    Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
    Citation
  • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
    		•