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534356 PRMT5 Inhibitor, CMP5

Selectively blocks EBV-mediated B lymphocyte transformation & induces lymphoma cell death.

PRMT5 Inhibitor, CMP5 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine, 2HCl, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine, 2HCl

Primary Target: PRMT5
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₂₁N₃•2HCl

Products

Catalog NumberPackaging Qty/Pack
5.34356.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable carbazole based compound that selectively inhibits PRMT5 and not PRMT1, PRMT4 & PRMT7 activity. Shown to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. Prevents Epstein-Barr virus (EBV)-driven B cell immortalization and restores miR-96 transcriptional activity. Dose-dependently induces lymphoma cell death over normal resting B lymphocytes.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number534356
Brand Family Calbiochem®
Synonyms1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine, 2HCl, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine, 2HCl
DescriptionPRMT5 Inhibitor, CMP5
References
ReferencesAlinari, L., et al. 2015. Blood. 125, 2530.
Product Information
FormYellow solid
FormulationSupplied as HCl salt.
Hill FormulaC₂₁H₂₁N₃•2HCl
Chemical formulaC₂₁H₂₁N₃•2HCl
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPRMT5
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.34356.0001 04054839117152

Documentation

PRMT5 Inhibitor, CMP5 SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Alinari, L., et al. 2015. Blood. 125, 2530.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-November-2016 JSW
Synonyms1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine, 2HCl, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine, 2HCl
DescriptionA cell-permeable carbazole based compound that selectively inhibits PRMT5 and not PRMT1, PRMT4 & PRMT7 activity. Shown to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. Prevents Epstein-Barr virus (EBV)-driven B cell immortalization and restores miR-96 transcriptional activity. Dose-dependently induces lymphoma cell death over normal resting B lymphocytes.
FormYellow solid
FormulationSupplied as HCl salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₂₁N₃•2HCl
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml) or H₂O (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAlinari, L., et al. 2015. Blood. 125, 2530.