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516620 Peroxynitrite - Calbiochem

Peroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.

Peroxynitrite - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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516620
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Overview

Replacement Information

Products

Catalog NumberPackaging Qty/Pack
516620-1SET Alu drum 1 set
Description
OverviewSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock.
Note: 1 set = 2 x 1 ml.
Catalogue Number516620
Brand Family Calbiochem®
References
ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
Product Information
ATP CompetitiveN
FormYellow liquid
FormulationSupplied in 4.7% NaOH at 160-200 mM.
ReversibleN
Quality LevelMQ100
Applications
ApplicationPeroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.
Biological Information
Primary TargetOxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 8-20/22-34

Contact with combustible material may cause fire.
Harmful by inhalation and if swallowed.
Causes burns.
S PhraseS: 3-28-36/37/39-45

Keep in a cool place.

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Oxidizer
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
516620-1SET 04055977198256

Documentation

Peroxynitrite - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Peroxynitrite - Calbiochem Certificates of Analysis

TitleLot Number
516620

References

Reference overview
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-November-2007 JSW
DescriptionSynthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε302 nm = 1670M-1cm-1 in 0.1 MNaOH.
FormYellow liquid
FormulationSupplied in 4.7% NaOH at 160-200 mM.
Intert gas (Yes/No) Packaged under inert gas
SolubilityPeroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsProtect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
Toxicity Oxidizer
ReferencesMarla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.