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521000 Phenylarsine Oxide - CAS 637-03-6 - Calbiochem

A membrane-permeable protein tyrosine phosphatase inhibitor (IC₅₀ = 18 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PAO, Oxophenylarsine, PTP Inhibitor IX, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II

Primary Target: Protein tyrosine phosphatase
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521000
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
637-03-6C₆H₅AsO

Products

Catalog NumberPackaging Qty/Pack
521000-250MG Alu drum 250 mg
Description
OverviewA membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).
Catalogue Number521000
Brand Family Calbiochem®
SynonymsPAO, Oxophenylarsine, PTP Inhibitor IX, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II
References
ReferencesTakahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Carey, J.O., et al. 1995. Diabetes 44, 1995.
Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.
Product Information
CAS number637-03-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₆H₅AsO
Chemical formulaC₆H₅AsO
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetProtein tyrosine phosphatase
Primary Target IC<sub>50</sub>18 µM against protein tyrosine phosphatase
Purity≥96% by titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCH8100000
Safety Information
R PhraseR: 26/27/28-34-40

Very toxic by inhalation, in contact with skin and if swallowed.
Causes burns.
Limited evidence of a carcinogenic effect.
S PhraseS: 26-27-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
521000-250MG 04055977271324

Documentation

Phenylarsine Oxide - CAS 637-03-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Phenylarsine Oxide - CAS 637-03-6 - Calbiochem Certificates of Analysis

TitleLot Number
521000

References

Reference overview
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Carey, J.O., et al. 1995. Diabetes 44, 1995.
Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-September-2008 JSW
SynonymsPAO, Oxophenylarsine, PTP Inhibitor IX, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II
DescriptionA membrane-permeable phosphotyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56lck protein tyrosine kinase. Blocks TNFα-dependent activation of the NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 µM, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.
FormWhite solid
CAS number637-03-6
RTECSCH8100000
Chemical formulaC₆H₅AsO
Structure formulaStructure formula
Purity≥96% by titration
SolubilityCHCl₃ (100 mg/ml) or DMSO (50 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Merck USA index14, 6949
ReferencesTakahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Carey, J.O., et al. 1995. Diabetes 44, 1995.
Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.