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525276 Phosphoramidon, Disodium Salt - Calbiochem

Inhibits some metalloendopeptidases.

Phosphoramidon, Disodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na

Primary Target: thermolysin
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₃₂N₃O₁₀P · 2Na

Products

Catalog NumberPackaging Qty/Pack
525276-5MG Plastic ampoule 5 mg
Description
OverviewInhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM).
Effective concentration: 1-10 µM.
Catalogue Number525276
Brand Family Calbiochem®
SynonymsN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
References
ReferencesBalwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
Howell, S., et al. 1993. Biochem. J. 290, 159.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₃H₃₂N₃O₁₀P · 2Na
Chemical formulaC₂₃H₃₂N₃O₁₀P · 2Na
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetthermolysin
Primary Target IC<sub>50</sub>4.6 µM against the conversion of big endothelin-1 to endothelin
PuritySingle spot by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
525276-5MG 04055977270648

Documentation

Phosphoramidon, Disodium Salt - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Phosphoramidon, Disodium Salt - Calbiochem Certificates of Analysis

TitleLot Number
525276

References

Reference overview
Balwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
Howell, S., et al. 1993. Biochem. J. 290, 159.

Citations

Title
  • Peter Oishi, et al. (2006) Nitric Oxide-Endothelin-1 Interactions After Surgically Induced Acute Increases in Pulmonary Blood Flow in the Intact Lamb. American Journal of Physiology Heart and Circulatory Physiology 290, H1922-1932.
  • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision26-August-2008 RFH
    SynonymsN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
    DescriptionInhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM).
    FormWhite lyophilized solid
    Chemical formulaC₂₃H₃₂N₃O₁₀P · 2Na
    PuritySingle spot by TLC
    SolubilityDMSO (10 mg/ml), methanol, or H₂O
    Storage Protect from light
    +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Standard Handling
    ReferencesBalwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
    Howell, S., et al. 1993. Biochem. J. 290, 159.
    Citation
  • Peter Oishi, et al. (2006) Nitric Oxide-Endothelin-1 Interactions After Surgically Induced Acute Increases in Pulmonary Blood Flow in the Intact Lamb. American Journal of Physiology Heart and Circulatory Physiology 290, H1922-1932.
  • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    		•