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528105 Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: GABA receptors
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528105
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
124-87-8C₁₅H₁₈O₇ . C₁₅H₁₆O₆

Products

Catalog NumberPackaging Qty/Pack
528105-100MG 100 mg
Description
OverviewA potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl– channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
Catalogue Number528105
Brand Family Calbiochem®
References
ReferencesQian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
Akaike, N., et al. 1985. Experientia 41, 70.
Product Information
CAS number124-87-8
ATP CompetitiveN
FormWhite to light yellow powder or crystals
Hill FormulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
Chemical formulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGABA receptors
Primary Target IC<sub>50</sub>240 nM against GABA receptors
Purity≥98% (mixture of Picrotoxin and picrotin) by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTJ9100000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
528105-100MG 04055977270488

Documentation

Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem Certificates of Analysis

TitleLot Number
528105

References

Reference overview
Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
Akaike, N., et al. 1985. Experientia 41, 70.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-March-2019 JSW
DescriptionA potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl- channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
FormWhite to light yellow powder or crystals
CAS number124-87-8
RTECSTJ9100000
Chemical formulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
Structure formulaStructure formula
Purity≥98% (mixture of Picrotoxin and picrotin) by HPLC
SolubilityEthanol (50 mg/ml) or basic aqueous solutions (3 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Toxicity Highly Toxic
Merck USA index14, 7415
ReferencesQian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
Akaike, N., et al. 1985. Experientia 41, 70.