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506132 Pifithrin-α - CAS 63208-82-2 - Calbiochem

A cell-permeable chemical inhibitor of p53.

Pifithrin-α - CAS 63208-82-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr

Primary Target: PS3
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506132
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
63208-82-2C₁₆H₁₈N₂OS·HBr

Products

Catalog NumberPackaging Qty/Pack
506132-10MG Plastic ampoule 10 mg
506132-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
Catalogue Number506132
Brand Family Calbiochem®
Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
References
ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
Ferber, D. 1999. Science 285, 1651.
Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
Komarov, P.G., et al. 1999. Science 285, 1733.
Product Information
CAS number63208-82-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₁₈N₂OS·HBr
Chemical formulaC₁₆H₁₈N₂OS·HBr
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPS3
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
506132-10MG 04055977199499
506132-5MG 04055977199505

Documentation

Pifithrin-α - CAS 63208-82-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Pifithrin-α - CAS 63208-82-2 - Calbiochem Certificates of Analysis

TitleLot Number
506132

References

Reference overview
Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
Ferber, D. 1999. Science 285, 1651.
Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
Komarov, P.G., et al. 1999. Science 285, 1733.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
DescriptionA reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number63208-82-2
Chemical formulaC₁₆H₁₈N₂OS·HBr
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
Toxicity Standard Handling
ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
Ferber, D. 1999. Science 285, 1651.
Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
Komarov, P.G., et al. 1999. Science 285, 1733.