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416154 Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem

Pre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

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416154
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
548-19-6C₃₂H₂₂O₁₀

Products

Catalog NumberPackaging Qty/Pack
416154-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 µM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
Catalogue Number416154
Brand Family Calbiochem®
Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
References
ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
Product Information
CAS number548-19-6
FormYellow solid
Hill FormulaC₃₂H₂₂O₁₀
Chemical formulaC₃₂H₂₂O₁₀
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
416154-10MG 04055977187786

Documentation

Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem Certificates of Analysis

TitleLot Number
416154

References

Reference overview
Kim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-September-2012 JSW
Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
DescriptionA naturally isolated Ginkgo biloba biflavanoid that acts as a cell-permeable, reversible inhibitor against spliceosome-mediated pre-mRNA splicing (IC50 and ICmax = 30 and 50 µM, respectively, in splicing assays using HeLa nuclear extract) by preventing the prespliceosome A complex from recruiting the U4/U5/U6 tri-snRNP (stable nuclear RNA and its associated proteins) to form B complex. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number548-19-6
Chemical formulaC₃₂H₂₂O₁₀
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.