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539211 Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III

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539211
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
17372-87-1C₂₉H₆Br₄O₅Na₂ • 3H₂O

Products

Catalog NumberPackaging Qty/Pack
539211-50MG Plastic ampoule 50 mg
Description
OverviewA xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
Catalogue Number539211
Brand Family Calbiochem®
SynonymsDisodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
References
ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
Product Information
CAS number17372-87-1
FormReddish brown solid
Hill FormulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
Chemical formulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90%
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 24/25-36/37/39-45

Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
539211-50MG 04055977268911

Documentation

Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem Certificates of Analysis

TitleLot Number
539211

References

Reference overview
Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2009 RFH
SynonymsDisodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
DescriptionA xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
FormReddish brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number17372-87-1
Chemical formulaC₂₉H₆Br₄O₅Na₂ • 3H₂O
Structure formulaStructure formula
Purity≥90%
SolubilityH₂O (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesCheng, D., et al. 2004. J. Biol. Chem. 279, 23892.